Professor

Professor Xianting Dingtop


500

Vitatop

Dr. Xianting Ding is Associate professor at School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University. He received his Ph.D. degree from Department of Mechanical Engineering at University of California, Los Angeles (UCLA) in 2012. His research interests focus on developing Personalized Therapy and Precision Medicine, including: 1) developing bio-sensors for early detection of cancer, infectious disease, metabolic diseases, age-related diseases, cardiovascular diseases, based on cellular electrochemical, impedance, mechanical and photonic signaling; 2) developing personalized treatment; optimizing drug combinations; studying drug-drug interactions; building up models for bio-complex systems, based on Feedback System Control (FSC), Microfluidics and Bio-MEMS; 3) Traditional Chinese Medicine (TCM) modernization, extraction, purification, and re-combination for treating ischemia, osteoporosis and depression.

He participated in the early investigation and development for 3 international research centers, including Institute for Cell Mimetic Space Exploration (CMISE, funded by NASA), Center for Cell Control (CCC, funded by NIH) and Institute for Personalized Medicine (IPM, funded by Chinese Central Organization Department). He is an editorial board member for Journal of the Association for Laboratory Automation (JALA) and Scientific Reports. He serves as a reviewer for 10 SCI journals, and has published 50 peer reviewed journal papers and filed 20 patents.

Research Interests: Personalized medicine; Drug Combination Optimization; Bio-sensors; Microfluidics; Bio-complex system modeling

 

丁显廷,中组部“青年千人”计划获得者,香港求是基金会“求是杰出青年”获得者。2012年3月获得美国加州大学洛杉矶分校(UCLA)博士学位,2013年1月进入上海交通大学生物医学工程学院、个体化医学研究院任特别研究员,与美国工程院院士、台湾中央研究院院士何志明(Chih-Ming Ho)教授一起工作,主要科研兴趣为:开展个体化医疗和精准医疗相关的诊断与治疗研究。
研究方向主要集中在:1)通过生物工程手段,如单细胞质谱流式技术(CyTOF)、基因组学和蛋白质组学的电化学信号(Electrochemical)、细胞力学信号(Mechano-biology)等,对癌症、传染病、代谢病等重大疾病开展早期诊断;2)通过工程反馈系统控制(Feedback System Control)、微纳米流体(Microfluidics)、微机电(Bio-MEMS)等手段,对组合药物进行复方优化,研究药物间相互作用,对生物复杂系统进行建模,以实现“因人而施药,并非因病而施药”的目的;3)中药现代化:对中药药材和中药古方中有效部位和有效单体进行提取、纯化、再复方,用于治疗包括缺血、皮肤修复、骨质疏松、抑郁症等疾病。
丁显廷博士参与过3个国际大型科研中心的建立;目前担任美国比尔.盖茨基金会(Bill & Melinda Gates Foundation) “肺结核和艾滋病组合药物的临床研发” 专项主要负责人,中国科技部十二五“新药创制重大专项”项目负责人,国家自然基金项目负责人。曾经或正在负责16个国际合作项目(合作研究所包括美国、日本、瑞士、意大利、台湾、香港等);2份SCI杂志(Journal of the Association for Laboratory Automation、Scientific Reports)的编委会成员(editorial board),已发表SCI论文50余篇;申请发明专利20余项。

研究方向:疾病早期诊断、多药组合、生物信息检测与传感、个体化医疗、生物复杂性分析与建模

 

期刊论文 Scientific Journal Articles:top

 

1.        Wenqiong Su#, Jiamei Xu, Xianting Ding*,” An electrochemical pH sensor based on the amino-functionalized graphene and polyaniline composite film”, IEEE Trans Nanobioscience, 2016, [Epub ahead of print], DOI: 10.1109/TNB.2016.2625842
2.        Shuopeng Liu#, Wenqiong Su, Xianting Ding*, “A Review on Microfluidic Paper-based Analytical Devices (μPADs) for  Glucose Detection”, Sensors, 2016,  16(12),  pii: E2086
3.        Jinjin Lin#, Hui Jiang, Xianting Ding*, “Synergistic combinations of five single drugs from Centella asiatica for neuronal differentiation”, Neuroreport, 2017 Jan 1;28(1):23-27
4.        Xianting Ding#*, Drug screening: Drug repositioning needs a rethink. Nature. 2016, 535(7612):355 (correspondence)
5.        HuiJiang#, Guoshuai Zheng, Junwei Lv, Heyu Chen, Jinjin Lin, Yiyang Li, Guorong Fan*, XiantingDing*, “Identification of Centella asiatica's effective ingredients for inducingthe neuronal differentiation”, Evidence-Based Complementary and Alternative Medicine, 2016, 2016:9634750
6.        Yue, Ji, Liu, Zhen, Cai, Xingyu, Ding, Xianting, *Chen, Shouhui, *Tao, Ke, *Zhao, Tingbao, “Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection”, Talanta, 2016, 150, pp 503-509,
7.        Yiwei Wang#, Jiayi Yu, Ran Cui, Jinjin Lin, and Xianting Ding*, “Curcumin in Treating Breast Cancer: A Review”, Journal of Laboratory Automation, 2016, 21(6), pp 723-731
8.        Dan Li#, Wei Deng*, Hu Xu, Yinxing Sun, Yuhong Wang, Shouhui Chen*, and Xianting Ding, “Electrochemical Investigation of Coenzyme Q10 on Silver Electrode in Ethanol Aqueous Solution and Its Determination Using Differential Pulse Voltammetry”, Journal of Laboratory Automation, 2016, 21(4):579-89
9.        Xianting Ding#, Bing Zhang, Jian Yang*, Zhijun Ma and Gang Fan, “Use of feedback system control in optimizing chemical combinations to synthesize nanoparticles with desired characteristics”, RSC Advances, 2016, 2016(6): 28322-28330
10.      Aleidy Silva#, Theodore Kee, Xianting Ding, Bai-Yu Lee,  Chih-Ming Ho* and Marcus Horwitz*,  “Output-Driven Feedback System Control Platform Optimizes Combinatorial Therapy of Tuberculosis using a Macrophage Cell Culture Model”, Proceedings of the National Academy of Sciences (PNAS), 2016, 113(15):E2172-9
11.      Hao Li#, Zhengyun Zhang, Zunqiang Zhou, Xianting Ding* and Guangwen Zhou*, “Optimal combination of gemcitabine, sorafenib and S-1 shows increased efficacy in treating cholangiocarcinoma in vitro and in vivo”, anti-cancer drugs, 2016, 27(7):600-608
12.      Patrycja Nowak-Sliwinska#*, Andrea Weiss, Xianting Ding, Paul J Dyson, Hubert van den Bergh, Arjan W Griffioen and Chih-Ming Ho*, Optimization of drug combinations using Feedback System Control, Nature Protocols, 2016, 11(2): 302-15
13.      Zhonghao Su#, JinYe#, Zhenxia Qin* and Xianting Ding*, Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro, Scientific Reports, 2015, 5: 18314
14.      Andrea Weiss#, Robert H. Berndsen, Xianting Ding*, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen and Patrycja Nowak-Sliwinska*, A streamlined search technology for identification of synergistic drug combinations, Scientific Reports, 2015, 5: 14508
15.      Xianting Ding#*, New Developments in Biosensing Technologies, Journal of Laboratory Automation, 2015, 20(4): 311–315
16.      Qi Liu#, Cheng Zhang#, Xianting Ding#, Hui Deng, Daming Zhang, Wei Cui, Hongwei Xu, Yingwei Wang, Wanhai Xu, Lei Lv, Hongyu Zhang, Yinghua He, Qiong Wu, Moshe Szyf, Chih-Ming Ho*, Jingde Zhu*, Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform, Scientific Reports, 2015, 5:11464
17.      Xianting Ding#*, Kyle Matsuo, Lin Xu, Jian Yang and Longpo Zheng, Optimized combinations of Bortezomib, Camptothecin and Doxorubicin show increased efficacy and reduced toxicity in treating oral cancer, Anti-Cancer Drugs, 2015, 26(5): 547-54
18.      Andrea Weiss#, Xianting Ding, Judy R. van Beijnum, Ieong Wong, Tse J. Wong, Robert H. Berndsen, Olivier Dormond, Marchien Dallinga, Li Shen, Reinier O. Schlingemann, Roberto Pili, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen, Patrycja Nowak-Sliwinska*, Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer, Angiogenesis, 2015, 18(3): 233-244
19.      Shuopeng Liu#, Wenqiong Su, Zonglin Li, Xianting Ding*, Electrochemical detection of lung Cancer specific microRNAs using 3D DNA origami nanostructures, Biosensors and Bioelectronics, 2015, 15(71): 57-61
20.      Zonglin Li#, Wenqiong Su, Shuopeng Liu, Xianting Ding*, An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH, Biosensors and Bioelectronics, 2015, 15(69): 287-293
21.      Shouhui Chen#, Qifeng Li#, Yan Xu, Hao Li, and Xianting Ding*, “Gold nanorods Bioconjugates for Intracellular Delivery and Cancer cell Apoptosis”, Journal of Laboratory Automation, 2015, 20(4): 418-422
22.      Wengqiong Su#, Xianting Ding*, Methods of Endotoxin Detection, Journal of Laboratory Automation, 2015, 20(4): 354-364
23.      Dan-dan Liu#, Yu-mei Xu, Xian-ting Ding, Jian Yang*, and Zhi-jun Ma, Utilizing the Plateau-Rayleigh Instability with Heat-Driven Nano-Biosensing Systems, Journal of Laboratory Automation, 2015, 20(4):463-70
24.      Yingxin Ma#, Hui Nie, Heyu Chen, Jiefu Li, Yunyi Hong, Ban Wang, Caixia Wang, Jie Zhang, Wei Cao, Mingchao Zhang, Yongning Xu, Xianting Ding, Shan Kai Yin, Xinkai Qu and Weihai Ying*, NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and  Ischemic Brain Injury: Current Advances and Therapeutic Implications,  Current Medicinal Chemistry, 2015, 22(10):1239-1247
25.      Xianting Ding#*, Ningxia Liu, Kyle Matsuo, Mingzhu Sun, Xin Zhao, Use of cell morphology as early bioindicator for viral infection, IET Nanobiotechnology, 2014, 8(1):24-30
26.      Hongquan Xu#*, Jessica Jaynes and Xianting Ding, Combining Two-Level and Three-Level Orthogonal Arrays for Factor Screening and Response Surface Exploration, Statistica Sinica, 2014,  24:269-289
27.      Yingxin Ma#, Danhong Wu, Xianting Ding, Weihai Ying*, CD38 plays key roles in both antioxidation and cell survival of H2O2-treated primary rodent astrocytes, Int J Physiol Pathophysiol Pharmacol, 2014, 6(2):102-108
28.      Ban Wang#, Yingxin Ma, Xiaoni Kong, Xianting Ding, Hongchen Gu, Tianqing Chu, Weihai Ying*, NAD+ Administration Decreases Doxorubicin-Induced Liver Damage of Mice by Enhancing Antioxidation Capacity and Decreasing DNA Damage,  Chemico-Biological Interactions, 2014 ,212 (5) :65–71
29.      Caixia Wang#, Heyu Chen , Jie Zhang , Yunyi Hong , Xianting Ding , Weihai Ying*, Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells, Int J Physiol Pathophysiol Pharmacol, 2014, 6(2):109-114
30.      Yunyi Hong#, Hui Nie, Danhong Wu, Xunbin Wei, Xianting Ding, Weihai Ying*, NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells, Neuroscience Letters, 2014, 7(560):46-50
31.      Weiping Wang#, Jinxing Guo, Shuwen Zhang, Jian Yang*, Xianting Ding, Xuehua Zhan, Numerical study on hydrodynamic characteristics of plate-fin heat exchanger using porous media approach, Computers & Chemical Engineering, 2014, 61(4):30-37
32.      Xianting Ding#*, Wenjia Liu, Andrea Weiss, Yiyang Li, Ieong Wong, Arjan W Griffioen, Hubert van den Bergh, Hongquan Xu, Patrycja Nowak-Sliwinska and Chih-Ming Ho, Discovery of a low order drug-cell response surface for applications in personalized medicine, Physical Biology, 2014, 11(6):065003
33.      Yoshitomo Honda#, Xianting Ding, Federico Mussano, Akira Wiberg, Chih-ming Ho* and Ichiro Nishimura*, Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control, Scientific Reports, 2013, 3:3420
34.      Xianting Ding#, Hongquan Xu*, Chanelle Hopper, Jian Yang and Chih-Ming Ho, Use of Fractional Factorial Designs in Antiviral Drug Studies, Quality and Reliability Engineering International, 2013, 29(2):299–304
35.      Hui Yu#, Wendy L Zhang, Xianting Ding, Ken Y Z Zheng, Chih-Ming  Ho, Karl W K Tsim and Yi-Kuen Lee*, Optimizing Combinations of Flavonoids Deriving from Astragali Radix in Activating the Regulatory Element of Erythropoietin by a Feedback System Control Scheme, Evidence-Based Complementary and Alternative Medicine, 2013, 2013(1):70-75
36.      Jessica Jaynes#, Xianting Ding, Hongquan Xu*, Weng Kee Wong, Chih-Ming Ho, Application of Fractional Factorial Designs to Study Drug Combinations, Statistics in Medicine, 2013, 32(2):307–318
37.      Weiping Wang #, Shuwen Zhang, Jian Yang*, Jinyang Zheng, Xianting Ding, Mengta Chou, Ping Tang, Xuehua Zhan, Effects of Distribution Channel Dimensions on Flow Distribution and Pressure Drop in a Plate-Fin Heat Exchanger, Chemical Engineering & Technology, 2013, 36(4):657-664
38.      Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, Thermal transpiration effect on the mass transfer and flow behaviors of the pressure-driven hydrogen gas flow, International Journal of Hydrogen Energy, 2012, 37(17):12474-12480
39.      Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump, Journal of Mechanical Engineering, 2012, 25(4):745-752
40.      Ieong Wong#, Xianting Ding#, Chunsheng Wu and Chih-Ming Ho*, Accurate and Effective Live Bacteria Microarray Patterning on Thick Polycationic Polymer Layer Co-Patterned with HMDS, RSC Advances, 2012, 2(20):7673-7676
41.      Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, A multi-scale flow analysis in hydrogen separation membranes using a coupled DSMC-SPH method, International Journal of Hydrogen Energy, 2012, 37(1):894-902
42.      Xianting Ding#, David Jesse Sanchez, Arash Shahangian, Ibrahim Al-Shyoukh, Genhong Cheng*, and Chih-Ming Ho*, Cascade search for HSV-1combinatorial drugs with high antiviral efficacy and low toxicity, International Journal of Nanomedicine, 2011, 7(2):2281-2292
43.      Hideaki Tsutsui#, Bahram Valamehr#,  Antreas Hindoyan, Rong Qiao,  Xianting Ding, Shuling Guo, Owen N. Witte,         Xin Liu,    Chih-Ming Ho* and Hong Wu*, An Optimized Small Molecule Inhibitor Cocktail Supports Long-Term Maintenance Of Human Embryonic Stem Cells, Nature Communication, 2011, 2:167
44.      Gang Liu#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, C Xu and JX Guo, The fluid-structure interaction analysis of elbows under a transient liquid slug, Journal of Engineering Thermophysics, 2010, 31:85-88

45.   基于毛细不稳定性的聚焦通道微液滴操控研究    刘丹丹;徐玉梅;杨健;马志军;丁显廷  轻工机械, 33(2), 2015 ; ISTP

 

专利PATENTS

1.        一种基于石墨烯/聚苯胺复合膜的pH检测电极,徐嘉媚;苏文琼;丁显廷, 2015/9/16, CN201510332959.X.
2.        一种基于石墨烯/PEDOT复合膜的pH检测电极,  徐嘉媚;苏文琼;丁显廷, 2015/9/9, CN201510330752.9.
3.        应用3D打印模板和模块化组装制备微流控芯片方法, 陈守慧;施金豆;叶磊;丁显廷, 2015/9/30, CN201510279518.8.
4.        微流控芯片及其乙烯基-巯基聚合材料和制备方法 , 刘文佳;苏文琼;丁显廷, 2015/6/24, 上海, CN201510141155.1.
5.        基于3D打印技术的微流控芯片制备方法及其应用 , 陈守慧;施金豆;叶磊;丁显廷, 2015/9/9, 上海, CN201510279519.2.
6.        基于茎环结构探针的电化学传感器及其制备方法 , 刘硕鹏;丁显廷;李宗霖;苏文琼, 2015/1/21, CN201410545481.4.
7.        一种用于NADH电化学检测的复合电极及其制备方法 , 李宗霖;丁显廷;刘硕鹏;苏文琼, 2015/1/28, CN201410549020.4.
8.        一种非均相紫外-芬顿氧化催化剂及其制备与应用 , 苏文琼;车顺爱;丁显廷, 2015/3/4, CN201410572458.4.
9.        一种紫外光助非均相芬顿氧化污水处理方法 , 苏文琼;车顺爱;丁显廷, 2015/3/25, CN201410571184.7.
10.      一种沙棘总黄酮提纯工艺 , 吕君蔚;姜慧;丁显廷,  2015/4/8, CN201410844325.8.
11.      一种积雪草提取物及其制备与应用, 姜慧;吕君蔚;丁显廷;林津津, 2015/1/14, CN201410561649.0.
12.      一种枸杞多糖的提纯工艺 , 吕君蔚;姜慧;丁显廷, 2015/4/22, CN201410838386.3.
13.      Dean Ho, Chih-Ming Ho, Yen Yun, Xianting Ding, Edward Chow, “A Hybrid Experimental-Analytical Platform for Population-Personalized Medicine and Population-Optimized Combinatorial Therapy”. U.S. utility patent, Attorney Docket No.: 102352-0380 ; UCLA Case 2015-226-1, 2015-1-12  
14.      Patrycja NOWAK-SLIWINSKA, Paul DYSON, Arjan GRIFFIOEN, Andrea WEISS, Hubert VAN DEN BERGH, Xianting DING, “Drug Combination for Treatment of Proliferative Diseases”, International Patent Application No.: PCT/EP2015/055246, Y/Ref.: 6.1380-PCT, O/Ref.: P2711PC00 / 0013-291 / ar-lm, 2015-03-12       
15.      Xianting Ding, Chih-Ming Ho, Ieong Wong, “Rapid Identification Of Optimized Inputs For Directing A Complex System Towards Desired End State”, U.S. provisional patent, No.: US61/753,842, 2013-1-17
16.      Xianting Ding, Yi-Kuen Lee, Karl Tsim, Hui Yu, and Chih-Ming Ho, “Optimizing traditional Chinese herbal medicines for increasing human red blood cells”, Chinese national patent pending, No.: PCT/CN2013/001169, 2012-9-29 
17.      Xianting Ding, Jian Yang, and Ieong Wong, “Synthesis of uniform AgI nanoparticles with complexant-free combinatorial surfactants”,U.S. provisional patent, No.: US61/509,373, 2011-11-14     
18.      Xianting Ding, Ieong Wong and Chih-Ming Ho, “A Fast, high throughput method for single bacterial patterning on glass surface”, U.S. provisional patent, No.: US61/559,333, 2011-7-19      
19.      Xianting Ding, David J Sanchez, Genhong Cheng and Chih-Ming Ho, “Case-specific optimal combinatory drug screening in HSV-1 inhibition”, U.S. provisional patent, No.: US61/623,482, 2012-4-12   

 

 

Professor Chih-Ming Hotop

Professor-Chih-Ming-Ho

Vitatop

Dr. Chih-Ming Ho holds the Ben Rich-Lockheed Martin Professor in UCLA School of Engineering. After receiving his Ph.D. from The Johns Hopkins University, Dr. Ho started his career at the University of Southern California and rose to the rank of Full Professor. In 1991, he moved to the University of California, Los Angeles to lead the establishment of the micro-electro-mechanical-system (MEMS) field in UCLA and served as the founding Director of the Center for Micro Systems. To this day, the UCLA MEMS research has been recognized as one of the top three programs in the world. He is the Director of NIH supported Center for Cell Control (CCC) and was the Director of NASA supported Institute for Cell Mimetic Space Exploration (CMISE). He served as UCLA Associate Vice Chancellor for Research from 2001 to 2005.

He is known for his contributions in bio-nano technology, micro/nano fluidics, and turbulence. He was ranked by ISI as one of the top 250 most cited researchers in all engineering category around the world. In 1997, Dr. Ho was inducted as a member of the National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica which honors scholars of Chinese origin with exceptional achievements in liberal arts and sciences. Dr. Ho holds seven honorary professorships. He has published 300 papers and 10 patents. He presented over 150 keynote talks in international conferences. Dr. Ho was elected Fellow of the American Physical Society as well as American Institute of Aeronautics and Astronautics for his contributions in a wide spectrum of technical areas.

In addition to his academic accomplishments, he has made extensive contributions to the professional societies around the world. He has chaired the Division of Fluid Dynamics (DFD) in American Physical Society, which is the leading platform in the United States for scientists interested in fundamental fluid dynamics. He was on the advisory board for AIAA Journal. He is a member of the IEEE/ASME JMEMS coordinating Committee. He was an Associate Editor of the ASME Journal of Fluids Engineering and an Associate Editor of the AIAA Journal. He also has served as a Guest Editor for Annual Review of Fluid Dynamics.

On the international level, he has served on advisory panels to provide assistance to many countries and regions, China, France, Hong Kong, Israel, Japan, Korea, Switzerland, Taiwan, Thailand, and United Kingdom on the developments of nano/micro technologies. Dr. Ho also has chaired or served on numerous organizing committees of international conferences on high technology topics.

Awardstop

Member: National Academy of Engineering
Citation: For contributions to the understanding and control of turbulent flows.

Member: Academia Sinica

Fellow: American Institute of Aeronautics and Astronautics
Citation: For seminal contributions to the basic understanding and control of turbulent shear flows and for pioneering contributions to applying microtransducers to aerospace science.

Fellow: American Physical Society
Citation: For contributions in understanding the sensitivity of free shear layers under perturbations or geometrical variations in initial conditions. His pioneering works have been served as bases for controlling the evolutions of turbulent free shear layers.

Patentstop

“Optical Pressure Transducer Randomly Distributed Fiber Optics,” United States Patent Number 4,158,310. Issued: June 19, 1979.

“Mixing Apparatus Using a Noncircular Jet of Small Aspect Ratio,” United States Patent Number 4,519,423. Issued: May 28, 1985.

“Electromagnetically Actuated Micromachined Flap,” United States Patent Number 5,629,918. Issued: May 13, 1997.

“Micromachined Hot-Wire Shear Stress Sensor,” U.S. Patent 5,883,310. Issued: March 16, 1999.

“A Method for Aligning and Forming Microelectromechanical Systems (MEMS) on Contouring Surfaces,” U.S. Patent 5,905,007, March 18, 1999. (CM Ho and WJ Li)

“Flexible Skin Incorporating MEMS Technology,” U.S. Patent 6,071,819. Issued June 6, 2000

“Apparatus and Method for Using Bubble as Virtual Valve in Microinjector to Eject Fluid,” U.S. Patent 6,102,530. Issued August 15, 2000

“Electronics Integrated with Bio-Reactor/Channel for Detection or Fabrication of Bio-Materials,” Patent Pending

“Electrochemical Detection of Mismatch in Nucleic Acids (EDEMNA),” Patent Pending

“Ultrasensitive Molecular Detection of Urinary Pathogens,” Patent Pending

“Micro-Chaotic Mixer,” U.S. Patent Number 6,902,313, 06/17/2005

“Control Devices for Evaporative Chemical Mixing/Reaction,” Patent Pending