Professors


Professor Xianting Ding


Dr. Xianting Ding is professor at School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University. He received his Ph.D. degree from Department of Mechanical Engineering at University of California, Los Angeles (UCLA) in 2012. His research interests focus on developing Personalized Therapy and Precision Medicine, including: 1) developing bio-sensors for early detection of cancer, infectious disease, metabolic diseases, age-related diseases, cardiovascular diseases, based on cellular electrochemical, impedance, mechanical and photonic signaling; 2) developing personalized treatment; optimizing drug combinations; studying drug-drug interactions; building up models for bio-complex systems, based on Feedback System Control (FSC), Microfluidics and Bio-MEMS; 3) Traditional Chinese Medicine (TCM) modernization, extraction, purification, and re-combination for treating ischemia, osteoporosis and depression.

He participated in the early investigation and development for 3 international research centers, including Institute for Cell Mimetic Space Exploration (CMISE, funded by NASA), Center for Cell Control (CCC, funded by NIH) and Institute for Personalized Medicine (IPM, funded by Chinese Central Organization Department). He is now leading 16 combinatorial-drug-optimization related international projects. He is the editorial board member for Scientific Reports and Journal of the Association for Laboratory Automation (JALA), the reviewer for 7 journals, published 50 peer reviewed journal papers and filed 20 national or international patents.

Research Interests: Personalized medicine; Drug Combination Optimization; Bio-sensors; Microfluidics; CyTOF

丁显廷,中国中组部“青年千人”计划获得者;香港求是基金会“求是杰出青年奖”获得者;美国南加州中华科学家工程师协会“青年科学家”奖获得者;上海市科协“飞翔计划”获得者。目前担任美国比尔.盖茨基金会(Bill & Melinda Gates Foundation)“肺结核和艾滋病组合药物的临床研发”专项,中国负责人;中国科技部十二五“重大新药创制专项”,项目负责人;军委科技委国防创新特区第一批启动项目,课题负责人;中国科技部“国家重点研发计划”前沿和共性技术创新,课题负责人;中国卫计委“艾滋病和病毒性肝炎等重大传染病防治”重大科技专项,课题负责人;国家自然基金项目负责人。2012年3月获得美国加州大学洛杉矶分校(UCLA)博士学位,2013年1月进入上海交通大学任特别研究员,与美国工程院院士、美国科学促进会(AAAS)院士、台湾中央研究院院士、中组部“顶尖千人计划”获得者、美国UCLA前科研副校长何志明(Chih-Ming Ho)院士共同创建上海交通大学个性化医学研究院,并担任研究院常务副院长。丁显廷博士参与过3个国际大型科研中心的建立:美国国家航空航天局(NASA)资助成立的Institute for Cell Mimetic Space Exploration (CMISE);美国国立卫生研究院(NIH)资助成立的Center for Cell Control(CCC);中国教育部和财政部资助成立的上海交通大学Institute for Personalized Medicine (IPM)。丁显廷博士是7个国际SCI期刊审稿人,2个国际SCI期刊的编委会成员,已发表包括Nature Communications, PNAS, Nature Protocols, Biosensors and Bioelectronics, Scientific Reports在内的国际期刊论文50余篇,申请发明专利30余项。目前还担任上海市免疫学会免疫遗传专业委员会,常务委员;上海市药学会药物治疗专业委员会,委员;上海医学会神经免疫学会,委员;天津市抗衰老学会健康大数据专业委员会,委员;国防创新特区“因控论”技术组,专家委员;全国卫生产业协会实验医学专家委员会青年委员会,委员等社会学术团体职务。曾经或正在负责14个国际合作项目(合作研究所包括美国、日本、瑞士、意大利、台湾、香港等)。

科研方向主要集中在个体化诊断、医疗相关的研究:1)多靶标诊断,通过生物工程手段,如微纳米流体(Microfluidics)、质谱流式技术(CyTOF)、生物电化学技术(bio-electrochemical)等,对癌症、传染病、代谢病等重大疾病开展多靶标的个体化早期诊断;2)多靶标医疗,通过工程反馈系统控制技术(Feedback System Control)、计算生物学(Computational Biology)等手段,研究多药物组合(包括中药和西药)与生物复杂系统间相互作用;3)中药现代化:对中药药材和中药古方中有效部位和有效单体进行提取、纯化、再复方,用于治疗包括缺血、骨质疏松、抑郁症和帕金森综合症等疾病。

研究方向:多靶点疾病早期诊断、药物组合优化、生物信息检测与传感、生物复杂性分析与建模、生物微流控芯片开发

SCIENTIFIC JOURNAL ARTICLES:

1. (Featured articles) Wenjia Liu#, Mingfang Zhang, Xiaoyan Liu, Alok Sharma, Xianting Ding*, “A Point-of-Need infrared mediated PCR platform with compatible lateral flow strip for HPV detection”, Biosensors and Bioelectronics, DOI: 10.1016/j.bios.2017.04.047

2. (Featured articles) Wenjia Liu#, Yiyang Li, Xianting Ding*, Cell adhesion pattern created by OSTE polymers, Biofabrication, 9(2):025006, 2017

3. Xiaolu Zhu# and Xianting Ding*, Study on a 3D Hydrogel-Based Culture Model for Characterizing Growth of Fibroblasts under Viral Infection and Drug Treatment, SLAS Discovery, 1:2472555217701247, 2017

4. Xiaolong Jia#, Yiyang Li#, Alok Sharma, Yulong Li, Guohai Xie, Guoyao Wang, Junhui Jiang, Yue Cheng, Xianting Ding*, Application of sequential two-level factorial design and three-level orthogonal array composite design (OACD) to study combination of 5 prostate cancer drugs, Computational biology and chemistry, 67:234-243, 2017

5. Boqian Wang#, Xianting Ding*, and Fei-Yue Wang*, Determination of Polynomial Degree in the Regression of Drug Combinations, IEEE/CAA Journal of Automatica Sinica, 4(1): 41-47, 2017

6. Ieong Wong#, Wenjia Liu#, Chih-Ming Ho* and Xianting Ding* Continuous Adaptive Population Reduction (CAPR) for Differential Evolution Optimization, SLAS Technology, 1:17,2017

7. (Featured articles) Bai-Yu Lee#, Daniel Clemens#, Aleidy Silva, Barbara Dillon, Saša Masleša-Galić, Susana Nava, Xianting Ding, Chih-Ming Ho*, and Marcus Horwitz*, "Drug Regimens Identified and Optimized by Output-Driven Platform Markedly Reduce Tuberculosis Treatment Time" , Nature Communications, 8:14183, 2017

8. Wenqiong Su#, Jiamei Xu, Xianting Ding*,” An electrochemical pH sensor based on the amino-functionalized graphene and polyaniline composite film”, IEEE Trans Nanobioscience, 2016, 15(8):812-819.

9. Shuopeng Liu#, Wenqiong Su, Xianting Ding*, “A Review on Microfluidic Paper-based Analytical Devices (μPADs) for Glucose Detection”, Sensors, 2016, 16(12), pii: E2086

10. Jinjin Lin#, Hui Jiang, Xianting Ding*, “Synergistic combinations of five single drugs from Centella asiatica for neuronal differentiation”, Neuroreport, 2017 Jan 1;28(1):23-27

11. Xianting Ding#*, Drug screening: Drug repositioning needs a rethink. Nature. 2016, 535(7612):355 (correspondence)

12. HuiJiang#, Guoshuai Zheng, Junwei Lv, Heyu Chen, Jinjin Lin, Yiyang Li, Guorong Fan*, XiantingDing*, “Identification of Centella asiatica's effective ingredients for inducingthe neuronal differentiation”, Evidence-Based Complementary and Alternative Medicine, 2016, 2016:9634750

13. Yue, Ji, Liu, Zhen, Cai, Xingyu, Ding, Xianting, *Chen, Shouhui, *Tao, Ke, *Zhao, Tingbao, “Bull serum albumin coated Au@Agnanorods as SERS probes for ultrasensitive osteosarcoma cell detection”, Talanta, 2016, 150, pp 503-509

14. Yiwei Wang#, Jiayi Yu, Ran Cui, Jinjin Lin, and Xianting Ding*, “Curcumin in Treating Breast Cancer: A Review”, Journal of Laboratory Automation, 2016, Epub, DOI: 10.1177/2211068216655524

15. Dan Li#, Wei Deng*, Hu Xu, Yinxing Sun, Yuhong Wang, Shouhui Chen*, and Xianting Ding, “Electrochemical Investigation of Coenzyme Q10 on Silver Electrode in Ethanol Aqueous Solution and Its Determination Using Differential Pulse Voltammetry”, Journal of Laboratory Automation, 2016, Epub, DOI: 10.1177/2211068216644442

16. Xianting Ding#, Bing Zhang, Jian Yang*, Zhijun Ma and Gang Fan, “Use of feedback system control in optimizing chemical combinations to synthesize nanoparticles with desired characteristics”, RSC Advances, 2016, 2016(6): 28322-28330

17. (Featured articles) Aleidy Silva#, Theodore Kee, Xianting Ding, Bai-Yu Lee, Chih-Ming Ho* and Marcus Horwitz*, “Output-Driven Feedback System Control Platform Optimizes Combinatorial Therapy of Tuberculosis using a Macrophage Cell Culture Model”, Proceedings of the National Academy of Sciences (PNAS), 2016, 113(15):E2172-9

18. Hao Li#, Zhengyun Zhang, Zunqiang Zhou, Xianting Ding* and Guangwen Zhou*, “Optimal combination of gemcitabine, sorafenib and S-1 shows increased efficacy in treating cholangiocarcinoma in vitro and in vivo”, anti-cancer drugs, 2016, 27(7):600-608

19. (Featured articles) Patrycja Nowak-Sliwinska#*, Andrea Weiss, Xianting Ding, Paul J Dyson, Hubert van den Bergh, Arjan W Griffioen and Chih-Ming Ho*, Optimization of drug combinations using Feedback System Control, Nature Protocols, 2016, 11(2): 302-15

20. (Featured articles) Zhonghao Su#, JinYe#, Zhenxia Qin* and Xianting Ding*, Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro, Scientific Reports, 2015, 5: 18314

21. (Featured articles) Andrea Weiss#, Robert H. Berndsen, Xianting Ding*, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen and Patrycja Nowak-Sliwinska*, A streamlined search technology for identification of synergistic drug combinations, Scientific Reports, 2015, 5: 14508

22. Xianting Ding#*, New Developments in Biosensing Technologies, Journal of Laboratory Automation, 2015, 20(4): 311–315

23. (Featured articles) Qi Liu#, Cheng Zhang#, Xianting Ding#, Hui Deng, Daming Zhang, Wei Cui, Hongwei Xu, Yingwei Wang, Wanhai Xu, Lei Lv, Hongyu Zhang, Yinghua He, Qiong Wu, Moshe Szyf, Chih-Ming Ho*, Jingde Zhu*, Preclinical optimization of a broad-spectrum anti-bladder cancer tri-drug regimen via the Feedback System Control (FSC) platform, Scientific Reports, 2015, 5:11464

24. Xianting Ding#*, Kyle Matsuo, Lin Xu, Jian Yang and Longpo Zheng, Optimized combinations of Bortezomib, Camptothecin and Doxorubicin show increased efficacy and reduced toxicity in treating oral cancer, Anti-Cancer Drugs, 2015, 26(5): 547-54

25. Andrea Weiss#, Xianting Ding, Judy R. van Beijnum, Ieong Wong, Tse J. Wong, Robert H. Berndsen, Olivier Dormond, Marchien Dallinga, Li Shen, Reinier O. Schlingemann, Roberto Pili, Chih-Ming Ho, Paul J. Dyson, Hubert van den Bergh, Arjan W. Griffioen, Patrycja Nowak-Sliwinska*, Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer, Angiogenesis, 2015, 18(3): 233-244

26. (Featured articles) Shuopeng Liu#, Wenqiong Su, Zonglin Li, Xianting Ding*, Electrochemical detection of lung Cancer specific microRNAs using 3D DNA origami nanostructures, Biosensors and Bioelectronics, 2015, 15(71): 57-61

27. (Featured articles) Zonglin Li#, Wenqiong Su, Shuopeng Liu, Xianting Ding*, An electrochemical biosensor based on DNA tetrahedron/graphene composite film for highly sensitive detection of NADH, Biosensors and Bioelectronics, 2015, 15(69): 287-293

28. Shouhui Chen#, Qifeng Li#, Yan Xu, Hao Li, and Xianting Ding*, “Gold nanorods Bioconjugates for Intracellular Delivery and Cancer cell Apoptosis”, Journal of Laboratory Automation, 2015, 20(4): 418-422

29. Wengqiong Su#, Xianting Ding*, Methods of Endotoxin Detection, Journal of Laboratory Automation, 2015, 20(4): 354-364

30. Dan-dan Liu#, Yu-mei Xu, Xian-ting Ding, Jian Yang*, and Zhi-jun Ma, Utilizing the Plateau-Rayleigh Instability with Heat-Driven Nano-Biosensing Systems, Journal of Laboratory Automation, 2015, 20(4):463-70

31. Yingxin Ma#, Hui Nie, Heyu Chen, Jiefu Li, Yunyi Hong, Ban Wang, Caixia Wang, Jie Zhang, Wei Cao, Mingchao Zhang, Yongning Xu, Xianting Ding, Shan Kai Yin, Xinkai Qu and Weihai Ying*, NAD+/NADH Metabolism and NAD+-Dependent Enzymes in Cell Death and Ischemic Brain Injury: Current Advances and Therapeutic Implications, Current Medicinal Chemistry, 2015, 22(10):1239-1247

32. Xianting Ding#*, Ningxia Liu, Kyle Matsuo, Mingzhu Sun, Xin Zhao, Use of cell morphology as early bioindicator for viral infection, IET Nanobiotechnology, 2014, 8(1):24-30

33. Hongquan Xu#*, Jessica Jaynes and Xianting Ding, Combining Two-Level and Three-Level Orthogonal Arrays for Factor Screening and Response Surface Exploration, Statistica Sinica, 2014, 24:269-289

34. Yingxin Ma#, Danhong Wu, Xianting Ding, Weihai Ying*, CD38 plays key roles in both antioxidation and cell survival of H2O2-treated primary rodent astrocytes, Int J Physiol Pathophysiol Pharmacol, 2014, 6(2):102-108

35. Ban Wang#, Yingxin Ma, Xiaoni Kong, Xianting Ding, Hongchen Gu, Tianqing Chu, Weihai Ying*, NAD+ Administration Decreases Doxorubicin-Induced Liver Damage of Mice by Enhancing Antioxidation Capacity and Decreasing DNA Damage, Chemico-Biological Interactions, 2014 ,212 (5) :65–71

36. Caixia Wang#, Heyu Chen , Jie Zhang , Yunyi Hong , Xianting Ding , Weihai Ying*, Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells, Int J Physiol Pathophysiol Pharmacol, 2014, 6(2):109-114

37. Yunyi Hong#, Hui Nie, Danhong Wu, Xunbin Wei, Xianting Ding, Weihai Ying*, NAD+ treatment prevents rotenone-induced apoptosis and necrosis of differentiated PC12 cells, Neuroscience Letters, 2014, 7(560):46-50

38. Weiping Wang#, Jinxing Guo, Shuwen Zhang, Jian Yang*, Xianting Ding, Xuehua Zhan, Numerical study on hydrodynamic characteristics of plate-fin heat exchanger using porous media approach, Computers & Chemical Engineering, 2014, 61(4):30-37

39. Xianting Ding#*, Wenjia Liu, Andrea Weiss, Yiyang Li, Ieong Wong, Arjan W Griffioen, Hubert van den Bergh, Hongquan Xu, Patrycja Nowak-Sliwinska and Chih-Ming Ho, Discovery of a low order drug-cell response surface for applications in personalized medicine, Physical Biology, 2014, 11(6):065003

40. (Featured articles) Yoshitomo Honda#, Xianting Ding, Federico Mussano, Akira Wiberg, Chih-ming Ho* and Ichiro Nishimura*, Guiding the osteogenic fate of mouse and human mesenchymal stem cells through feedback system control, Scientific Reports, 2013, 3:3420

41. Xianting Ding#, Hongquan Xu*, Chanelle Hopper, Jian Yang and Chih-Ming Ho, Use of Fractional Factorial Designs in Antiviral Drug Studies, Quality and Reliability Engineering International, 2013, 29(2):299–304

42. Hui Yu#, Wendy L Zhang, Xianting Ding, Ken Y Z Zheng, Chih-Ming Ho, Karl W K Tsim and Yi-Kuen Lee*, Optimizing Combinations of Flavonoids Deriving from Astragali Radix in Activating the Regulatory Element of Erythropoietin by a Feedback System Control Scheme, Evidence-Based Complementary and Alternative Medicine, 2013, 2013(1):70-75

43. Jessica Jaynes#, Xianting Ding, Hongquan Xu*, Weng Kee Wong, Chih-Ming Ho, Application of Fractional Factorial Designs to Study Drug Combinations, Statistics in Medicine, 2013, 32(2):307–318

44. Weiping Wang #, Shuwen Zhang, Jian Yang*, Jinyang Zheng, Xianting Ding, Mengta Chou, Ping Tang, Xuehua Zhan, Effects of Distribution Channel Dimensions on Flow Distribution and Pressure Drop in a Plate-Fin Heat Exchanger, Chemical Engineering & Technology, 2013, 36(4):657-664

45. Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, Thermal transpiration effect on the mass transfer and flow behaviors of the pressure-driven hydrogen gas flow, International Journal of Hydrogen Energy, 2012, 37(17):12474-12480

46. Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, Rarefaction and Temperature Gradient Effect on the Performance of the Knudsen Pump, Journal of Mechanical Engineering, 2012, 25(4):745-752

47. Ieong Wong#, Xianting Ding#, Chunsheng Wu and Chih-Ming Ho*, Accurate and Effective Live Bacteria Microarray Patterning on Thick Polycationic Polymer Layer Co-Patterned with HMDS, RSC Advances, 2012, 2(20):7673-7676

48. Jianjun Ye#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, Weizhong Li, Cong Chen, A multi-scale flow analysis in hydrogen separation membranes using a coupled DSMC-SPH method, International Journal of Hydrogen Energy, 2012, 37(1):894-902

49. (Featured articles) Xianting Ding#, David Jesse Sanchez, Arash Shahangian, Ibrahim Al-Shyoukh, Genhong Cheng*, and Chih-Ming Ho*, Cascade search for HSV-1combinatorial drugs with high antiviral efficacy and low toxicity, International Journal of Nanomedicine, 2011, 7(2):2281-2292

50. (Featured articles) Hideaki Tsutsui#, Bahram Valamehr#, Antreas Hindoyan, Rong Qiao, Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho* and Hong Wu*, An Optimized Small Molecule Inhibitor Cocktail Supports Long-Term Maintenance Of Human Embryonic Stem Cells, Nature Communication, 2011, 2:167

51. Gang Liu#, Jian Yang*, Jinyang Zheng, Xianting Ding, Ieong Wong, C Xu and JX Guo, The fluid-structure interaction analysis of elbows under a transient liquid slug, Journal of Engineering Thermophysics, 2010, 31:85-88

 


Professor Chih-Ming Ho

Dr. Chih-Ming Ho holds the Ben Rich-Lockheed Martin Professor in UCLA School of Engineering. After receiving his Ph.D. from The Johns Hopkins University, Dr. Ho started his career at the University of Southern California and rose to the rank of Full Professor. In 1991, he moved to the University of California, Los Angeles to lead the establishment of the micro-electro-mechanical-system (MEMS) field in UCLA and served as the founding Director of the Center for Micro Systems. To this day, the UCLA MEMS research has been recognized as one of the top three programs in the world. He is the Director of NIH supported Center for Cell Control (CCC) and was the Director of NASA supported Institute for Cell Mimetic Space Exploration (CMISE). He served as UCLA Associate Vice Chancellor for Research from 2001 to 2005.
He is known for his contributions in bio-nano technology, micro/nano fluidics, and turbulence. He was ranked by ISI as one of the top 250 most cited researchers in all engineering category around the world. In 1997, Dr. Ho was inducted as a member of the National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica which honors scholars of Chinese origin with exceptional achievements in liberal arts and sciences. Dr. Ho holds seven honorary professorships. He has published 300 papers and 10 patents. He presented over 150 keynote talks in international conferences. Dr. Ho was elected Fellow of the American Physical Society as well as American Institute of Aeronautics and Astronautics for his contributions in a wide spectrum of technical areas.
In addition to his academic accomplishments, he has made extensive contributions to the professional societies around the world. He has chaired the Division of Fluid Dynamics (DFD) in American Physical Society, which is the leading platform in the United States for scientists interested in fundamental fluid dynamics. He was on the advisory board for AIAA Journal. He is a member of the IEEE/ASME JMEMS coordinating Committee. He was an Associate Editor of the ASME Journal of Fluids Engineering and an Associate Editor of the AIAA Journal. He also has served as a Guest Editor for Annual Review of Fluid Dynamics.
On the international level, he has served on advisory panels to provide assistance to many countries and regions, China, France, Hong Kong, Israel, Japan, Korea, Switzerland, Taiwan, Thailand, and United Kingdom on the developments of nano/micro technologies. Dr. Ho also has chaired or served on numerous organizing committees of international conferences on high technology topics.

AWARDS

Member: National Academy of Engineering
Citation: For contributions to the understanding and control of turbulent flows.
Member: Academia Sinica
Fellow: American Institute of Aeronautics and Astronautics
Citation: For seminal contributions to the basic understanding and control of turbulent shear flows and for pioneering contributions to applying microtransducers to aerospace science.
Fellow: American Physical Society
Citation: For contributions in understanding the sensitivity of free shear layers under perturbations or geometrical variations in initial conditions. His pioneering works have been served as bases for controlling the evolutions of turbulent free shear layers.

PATENTS

“Optical Pressure Transducer Randomly Distributed Fiber Optics,” United States Patent Number 4,158,310. Issued: June 19, 1979.
“Mixing Apparatus Using a Noncircular Jet of Small Aspect Ratio,” United States Patent Number 4,519,423. Issued: May 28, 1985.
“Electromagnetically Actuated Micromachined Flap,” United States Patent Number 5,629,918. Issued: May 13, 1997.
“Micromachined Hot-Wire Shear Stress Sensor,” U.S. Patent 5,883,310. Issued: March 16, 1999.
“A Method for Aligning and Forming Microelectromechanical Systems (MEMS) on Contouring Surfaces,” U.S. Patent 5,905,007, March 18, 1999. (CM Ho and WJ Li)
“Flexible Skin Incorporating MEMS Technology,” U.S. Patent 6,071,819. Issued June 6, 2000
“Apparatus and Method for Using Bubble as Virtual Valve in Microinjector to Eject Fluid,” U.S. Patent 6,102,530. Issued August 15, 2000
“Electronics Integrated with Bio-Reactor/Channel for Detection or Fabrication of Bio-Materials,” Patent Pending
“Electrochemical Detection of Mismatch in Nucleic Acids (EDEMNA),” Patent Pending
“Ultrasensitive Molecular Detection of Urinary Pathogens,” Patent Pending
“Micro-Chaotic Mixer,” U.S. Patent Number 6,902,313, 06/17/2005
“Control Devices for Evaporative Chemical Mixing/Reaction,” Patent Pending